There's still a few weeks left in 2010, but it looks like the most watched YouTube videos of 2010 are as follows:

1. BED INTRUDER SONG!!! (now on iTunes)
2. TIK TOK KESHA Parody: Glitter Puke – Key of Awe$ome #13
3. Greyson Chance Singing Paparazzi
4. Annoying Orange Wazzup
5. Old Spice | The Man Your Man Could Smell Like
6. Yosemitebear Mountain Giant Double Rainbow 1-8-10
7. OK Go – This Too Shall Pass – Rube Goldberg Machine version
8. THE TWILIGHT SAGA: ECLIPSE – Trailer
9. Jimmy Surprises Bieber Fan
10. Ken Block's Gymkhana THREE, Part 2; Ultimate Playground; l'Autodrome

I'm a big fan of the Autotune the News guys, so I'm glad they did so well… although I didn't actually like the Bed Intruder Song very much.  In fact, I only like the Greyson Chance video, the Double Rainbow video, and the Ok Go video (all of which I put on this blog at one time or another).