I Tivo’d but haven’t watched the second episode.  Lance Mannion (who missed the pilot) liveblogged it.  As his wrap-up suggests, he (like me) was a little underwhelmed, but willing to give it a chance:

I’m going to give Studio 60 a couple more chances.  West Wing made me grumpy like this for the first few episodes—and there were things about it that I never stopped being grumpy about—but I was glad I stuck with it.  I stuck with West Wing for Martin Sheen and Rob Lowe. I’m sticking with Studio 60 for Steven Weber and Matt Perry, who so far, seems to be the only character on the show who understands that comedy is harder than dying.

UPDATE:  This is the best written review of Aaron Sorkin and Studio 60 yet.  I agree with everything in it.